APP Antikörper (C-Term)

Produktnummer ABIN361390

Produktdetails anti-APP Antikörper

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Bindungsspezifität: C-Term

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Specific for ~115k APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen.

Kreuzreaktivität: Maus, Ratte (Rattus)

Homologie: canine, chicken, human, mouse, non-human primate

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Andere Bezeichnung: APP (APP Produkte)

Hintergrund: A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003, Ando et al., 2001). Anti-Amyloid Precursor Protein Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115k APP protein.

Molekulargewicht: '115 kDa

Gen-ID: 54226

UniProt: P08592

Pathways: Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour