THRB Antikörper (N-Term)

Produktnummer ABIN361385

Der Maus Monoklonal Anti-THRB-Antikörper wurde für WB validiert. Er ist geeignet, THRB in Proben von Human zu detektieren.

Kurzübersicht für THRB Antikörper (N-Term) (ABIN361385)

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser THRB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 2386

Produktdetails anti-THRB Antikörper

Bindungsspezifität: N-Term

Spezifität: Specific for the ~55k TR-ß protein.

Kreuzreaktivität: Human

Aufreinigung: Protein G purified culture supernatant

Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Andere Bezeichnung: THRB

Hintergrund: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, -Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR- protein.

Molekulargewicht: '55 kDa

Gen-ID: 7068

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound