THRA Antikörper (N-Term)

Produktnummer ABIN361382

Der Maus Monoklonal Anti-THRA-Antikörper wurde für WB validiert. Er ist geeignet, THRA in Proben von Human zu detektieren.

Kurzübersicht für THRA Antikörper (N-Term) (ABIN361382)

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser THRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 2103

Produktdetails anti-THRA Antikörper

Bindungsspezifität: N-Term

Spezifität: Specific for the ~50k TR-a1 and the ~58k TR-a2 proteins.

Kreuzreaktivität: Human, Ratte (Rattus)

Homologie: canine, mouse, non-human primate

Aufreinigung: Protein G purified culture supernatant

Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu THRA

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Andere Bezeichnung: THRA

Hintergrund: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, a1/a2-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-a1 and the ~58k TR-a2 protein.

Molekulargewicht: 50/58 kDa

Gen-ID: 7067

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development