UCHL1 Antikörper

Produktnummer ABIN361370

Der Huhn Polyklonal Anti-UCHL1-Antikörper wurde für WB und IF validiert. Er ist geeignet, UCHL1 in Proben von Human zu detektieren.

Kurzübersicht für UCHL1 Antikörper (ABIN361370)

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reaktivität: Human

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser UCHL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-UCHL1 Antikörper

Spezifität: Specific for the ~24kDa UCHL1 protein. It is expected that it will work on other mammalian tissues.

Kreuzreaktivität: Rind (Kuh), Human, Maus, Ratte (Rattus)

Homologie: most mammalian

Aufreinigung: Total IgY fraction

Immunogen: Recombinant full length human UCHL1 purified from E. coli

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:2,500 IF: 1:500 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: total IgY fraction in PBS + 10 mM Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu UCHL1

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Andere Bezeichnung: UCHL1

Hintergrund: Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker. Anti-UCHL1

Molekulargewicht: '24 kDa

Gen-ID: 7365

UniProt: P09936

Pathways: Feeding Behaviour