Peripherin Antikörper

Produktnummer ABIN361364

Der Huhn Polyklonal Anti-Peripherin-Antikörper wurde für WB und IF validiert. Er ist geeignet, Peripherin in Proben von Ratte zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Peripherin Antikörper (ABIN361364)

Target: Peripherin (PRPH)

Reaktivität: Ratte

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser Peripherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Peripherin Antikörper

Spezifität: Specific for the ~57kDa peripherin protein.

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Homologie: most mammalian

Aufreinigung: Total IgY fraction

Immunogen: Recombinant rat peripherin expressed in and purified from E. coli

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB:1:1,000 IF: 1:500 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: total IgY fraction in PBS + 10 mM Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-Peripherin Antikörper (ABIN361364)

Olson, Abdus-Saboor, Cui, Burdge, Raabe, Ma, Luo: "Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors." in: eLife, Vol. 6, (2018) (PubMed).

Details zu Peripherin

Target: Peripherin (PRPH)

Andere Bezeichnung: PRPH

Hintergrund: Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. Anti-Peripherin Western blot of rat cerebellar lysate showing specific immunolabeling of the ~ 57k peripherin protein.

Molekulargewicht: '57 kDa

Gen-ID: 3414

UniProt: P21807