Periostin Antikörper

Produktnummer ABIN361362

Dieses Anti-Periostin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Periostin in WB und IHC. Geeignet für Maus.

Kurzübersicht für Periostin Antikörper (ABIN361362)

Target: Periostin (POSTN)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Periostin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Periostin Antikörper

Spezifität: The antibody has been directly tested for reactivity in chicken, human, mouse and rat. Based on the homology of the immunogen with other species, we expect that this antibody will recognize periostin in most, if not all, species of mammals, birds, amphibians, and fishes. Specific for three periostin bands around ~93 kDa in mouse lung extract. The immunogenic peptide is present in all known splice variants of periostin and therefore this antibody recognizes all known molecular forms of periostin. The antibody also works well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigenretrieval protocol (incubate slides for 20 minutes at 90° C in 10 mM sodium citrate (pH 6.0)/ 0.1 % Tween-20).

Kreuzreaktivität: Huhn, Human, Maus

Homologie: most mammalian, avian, amphibian and fishes

Aufreinigung: Antigen Affinity Purified

Immunogen: Synthetic peptide corresponding to amino acid residues from the fasciclin domain 1 of mouse periostin

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1,000 IHC: 1:100 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: ~ 0.5 mg/ml

Buffer: 100 μL in PBS

Lagerung: -20 °C

Details zu Periostin

Target: Periostin (POSTN)

Andere Bezeichnung: POSTN

Hintergrund: Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008).

Molekulargewicht: '93 kDa

Gen-ID: 50706

UniProt: Q62009