Thymidine Glycol Antikörper

Produktnummer ABIN361277

Der Maus Monoklonal anti-Thymidine Glycol Antikörper wird verwendet zum Nachweis von Thymidine Glycol in Proben von Chemical. Er wurde validiert für IHC.

Kurzübersicht für Thymidine Glycol Antikörper (ABIN361277)

Target: Thymidine Glycol (TG)

Reaktivität: Chemical

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Thymidine Glycol Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: 2E8

Produktdetails anti-Thymidine Glycol Antikörper

Spezifität: Specific to DNA containing thymidine glycol. Cross reactivity is checked to oxidized dC polymer, oxidized dG polymer and oxidized dA polymer.

Immunogen: Thymidine glycol polymer

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Tested for IHC. User should determine optimum titer for each application.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: 100ug/ml

Buffer: 100?g/mL IgG in 10 mM Phosphate buffered saline, pH7.4 containing 1.0 % BSA

Lagerung: -20 °C

Details zu Thymidine Glycol

Target: Thymidine Glycol (TG)

Substanzklasse: Chemical

Hintergrund: Thymidineglycol (TG) is one of the major oxidation products of DNA. Thymidine (T) can be damaged by oxidative stress such as radiation and energy metabolism. Two different pathways to form TG have been suggested. Deoxythymidine in DNA is directly oxidised by hydroxy radical, to form TG. TG can be also formed through an intermediate thymidine chlorohydrin, which is derived from hypochlorous acid (HOCl) from neutrophil myeloperoxidase. Thymidineglycol is derived from DNA, not from RNA. TG is the oxidative stress marker secific for DNA damage.