TWSG1 Antikörper

Produktnummer ABIN360945

Der Ratte Monoklonal anti-TWSG1 Antikörper (Klon 7D19) (ABIN360945) detektiert spezifisch TWSG1 in WB und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für TWSG1 Antikörper (ABIN360945)

Target: TWSG1 (Twisted Gastrulation Homolog 1 (TWSG1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser TWSG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 7D19

Produktdetails anti-TWSG1 Antikörper

Spezifität: This antibody detects Mouse TSG. Other species not tested.

Aufreinigung: Protein A/G Affinity Chromatography

Immunogen: Purified Mouse Recombinant TSG

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry on frozen sections: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μL/mL.

Buffer: PBS, None

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TWSG1

Target: TWSG1 (Twisted Gastrulation Homolog 1 (TWSG1))

Andere Bezeichnung: TWSG1 / Tsg

Hintergrund: Twisted gastrulation (TSG) is a secreted, cysteine-rich protein that plays a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating BMP signaling. TSG was originally identified in Drosophila melanogaster and shown to be required for the differentiation of the dorsal amnioserosa cells. Studies of expression and function of Twisted Gastrulation have been performed in Drosophila and Xenopus. Xenopus TSG is expressed in the ventral regions of the embryo during gastrulation, mimicking the BMP-4 expression pattern. TSG is expressed in dorsal cells of the blastoderm embryo, where there are also high levels of activity of Dpp and Screw. Vertebrate TSGs were subsequently cloned in mouse, human, zebrafish and frog. TSG acts as an agonist for BMP signaling by modulating the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. The N-terminal domain of TSG can bind BMP protein directly in vitro and shows BMP antagonist activity.Synonyms: Twisted gastrulation protein homolog 1

Gen-ID: 65960

NCBI Accession: NP_075540

UniProt: Q9EP52