TREM1 Antikörper (Extracellular Domain)

Produktnummer ABIN360943

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch TREM1 in WB und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für TREM1 Antikörper (Extracellular Domain) (ABIN360943)

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser TREM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 3C66

Produktdetails anti-TREM1 Antikörper

Bindungsspezifität: Extracellular Domain

Aufreinigung: Affinity Chromatography on Protein A/G.

Immunogen: Purified Mouse Recombinant TREM-1 extracellular domain.

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Western blotting: 1/500-1000. Immunohistochemistry on Frozen Sections: 1/50-100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 200 μL sterile PBS and the final concentration is 0.5 mg/mL.

Buffer: PBS without preservatives or stabilizers

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The lyophilized IgG is stable at 2-8 °C for one month and for one year when kept at -20 °C. Reconstituted antibody can also be aliquotted and stored at -20 °C to -70 °C for 6 months without detectable loss of activity.

Haltbarkeit: 12 months

Details zu TREM1

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Andere Bezeichnung: TREM1

Hintergrund: TREM1 is also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. TREM1 is a Type I membrane protein that contains an immunoglobulin-like V-type domain. An alternatively spliced protein variant may be secreted. TREM1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes), TREM1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock.Synonyms: Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1

Molekulargewicht: 26 kDa

NCBI Accession: NM_021406

UniProt: Q9JKE2