ARTN Antikörper
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- Target Alle ARTN Antikörper anzeigen
- ARTN (Artemin (ARTN))
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Reaktivität
- Maus
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Wirt
- Ratte
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Klonalität
- Monoklonal
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Konjugat
- Dieser ARTN Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- This antibody detects Mouse Artemin.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Mouse.
- Aufreinigung
- Affinity Chromatography on Protein A/G.
- Immunogen
- Mouse Recombinant Artemin.
- Klon
- 6G32
- Isotyp
- IgG2
- Top Product
- Discover our top product ARTN Primärantikörper
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- Applikationshinweise
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Western Blot: 1/500-1/1000. Immunohistochemistry on Frozen Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- Restore with 200 μL sterile PBS (final concentration = 500 μg/mL).
- Buffer
- 0.2 μm filtered PBS solution
- Konservierungsmittel
- Without preservative
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- ARTN (Artemin (ARTN))
- Andere Bezeichnung
- Artemin (ARTN Produkte)
- Synonyme
- ARTN antikoerper, ENOVIN antikoerper, EVN antikoerper, NBN antikoerper, neublastin antikoerper, artemin antikoerper, ARTN antikoerper, Artn antikoerper
- Hintergrund
- Artemin is a member of the Glia Cel-lDerived Neurotrophic factor (GDNF) family ligands, which include GDNF, Persephin, Artemin, and Neurturin. GDNF family ligands are distant members of the Transforming Growth Factor β (TGFβ) superfamily. Similar to other TGFβ family proteins, Artemin is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Artemin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond. Biologically active Artemin is a disulfide-linked homodimer of the carboxyterminal 113 amino acid residues. Mature mouse Artemin shares 88.5 % amino acid sequence similarity with human Artemin. Mature Artemin also shares approximately 40 % amino acid sequence identity with the other three members of the GDNF family ligands. Bioactivities of all GDNF family ligands are mediated through a receptor complex composed of a high affinity ligand binding component (GFRα1GFRα4) and a common signaling component, cRET (receptor tyrosine kinase). Artemin prefers to bind to GFRα3 and activites the GFRα3RET. However, in the presence of RET, it can bind to GFRα1 as well. Artemin has been shown to promote the survival and growth of various peripheral and central neurons, including sympathetic and dopaminergic neurons. It may also play an important role in the development of sympathetic neurons and several organs.Synonyms: ARTN, EVN, Enovin, Neublastin
- Molekulargewicht
- 24 kDa.
- Gen-ID
- 11876
- NCBI Accession
- NP_033841
- UniProt
- Q9Z0L2
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