PAK6 Antikörper (AA 131-146)

Produktnummer ABIN360326

Der Kaninchen Polyklonal Anti-PAK6-Antikörper wurde für WB, IP und EIA validiert. Er ist geeignet, PAK6 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für PAK6 Antikörper (AA 131-146) (ABIN360326)

Target: PAK6 (P21-Activated Kinase 6 (PAK6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Produktdetails anti-PAK6 Antikörper

Bindungsspezifität: AA 131-146

Spezifität: This antibody reacts to PAK6.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from aa 131~146 of human PAK6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunoprecipitation: 1/100. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Referenzen für anti-PAK6 Antikörper (ABIN360326)

Cheng, Yang, Wang, Tien, Shun, Huang, Hsiao, Hua: "Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein." in: Oncogene, Vol. 37, Issue 13, pp. 1730-1742, (2019) (PubMed).

Details zu PAK6

Target: PAK6 (P21-Activated Kinase 6 (PAK6))

Andere Bezeichnung: PAK6

Hintergrund: The PAK6 protein shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.Synonyms: PAK-5, PAK-6, PAK5, Serine/threonine-protein kinase PAK 6, p21-activated kinase 6

Gen-ID: 56924

NCBI Accession: NP_001122100

UniProt: Q9NQU5