CDKL5 Antikörper (C-Term)

Produktnummer ABIN359452

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CDKL5 in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für CDKL5 Antikörper (C-Term) (ABIN359452)

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKL5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CDKL5 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects CDKL5 (STK9) at C-term.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human STK9.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 10 - 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Details zu CDKL5

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Andere Bezeichnung: CDKL5 / STK9

Hintergrund: Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.Synonyms: Cyclin-dependent kinase-like 5, Serine/threonine protein kinase 9

Molekulargewicht: 115537 Da

Gen-ID: 6792, 9606

UniProt: O76039

Pathways: Regulation of Cell Size