Ataxin 3 Antikörper (N-Term)

Produktnummer ABIN357621

Dieses Anti-Ataxin 3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Ataxin 3 in WB, IHC (p) und EIA. Geeignet für Human.

Kurzübersicht für Ataxin 3 Antikörper (N-Term) (ABIN357621)

Target: Ataxin 3 (ATXN3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ataxin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Ataxin 3 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody is specific to Ataxin-3 (N-term).

Aufreinigung: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MJD.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu Ataxin 3

Target: Ataxin 3 (ATXN3)

Andere Bezeichnung: Ataxin-3

Hintergrund: Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.Synonyms: ATX3, ATXN3, MJD, MJD1, Machado-Joseph disease protein 1, SCA3, Spinocerebellar ataxia type 3 protein

Molekulargewicht: 43450 Da

Gen-ID: 4287, 9606

UniProt: P54252