PYGM Antikörper (C-Term)

Produktnummer ABIN356948

Der Kaninchen Polyklonal Anti-PYGM-Antikörper wurde für WB und EIA validiert. Er ist geeignet, PYGM in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für PYGM Antikörper (C-Term) (ABIN356948)

Target: PYGM (Phosphorylase, Glycogen, Muscle (PYGM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYGM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-PYGM Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects PYGM at C-term.

Aufreinigung: Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PYGM.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 10 - 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-PYGM Antikörper (ABIN356948)

Hathout, Marathi, Rayavarapu, Zhang, Brown, Seol, Gordish-Dressman, Cirak, Bello, Nagaraju, Partridge, Hoffman, Takeda, Mah, Henricson, McDonald: "Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients." in: Human molecular genetics, Vol. 23, Issue 24, pp. 6458-69, (2015) (PubMed).

Details zu PYGM

Target: PYGM (Phosphorylase, Glycogen, Muscle (PYGM))

Andere Bezeichnung: Glycogen Phosphorylase Muscle Form

Hintergrund: PYGM catalyzes and regulates the breakdown of glycogen to glucose-1-phosphate. Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5), also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.Synonyms: GPMM, Myophosphorylase, PYGM, Phosphorylase A, Phosphorylase B

Molekulargewicht: 97092 Da

Gen-ID: 5837, 9606

UniProt: P11217

Pathways: Cellular Glucan Metabolic Process