BST1 Antikörper

Produktnummer ABIN356330

Der Maus Monoklonal anti-BST1 Antikörper wird verwendet zum Nachweis von BST1 in Proben von Human. Er wurde validiert für IF, IHC (fro) und IHC (p).

Kurzübersicht für BST1 Antikörper (ABIN356330)

Target: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BST1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TN218

Produktdetails anti-BST1 Antikörper

Produktmerkmale: Synonyms: Blood Group Tn Antigen

Aufreinigung: PBS, pH 7.4 containing 0.05% Sodium Azide as preservative.

Immunogen: Asialo ovine submaxillary mucin (AOSM). Remarks: Molecular weight of antigen: Several HM weight glycoproteins. Epitope: alpha GalNacOSer/Thr.

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears)For IHC dilute concentared antibody at 1/50-1/100, use streptavidinapprox. biotin system orpolymer system, incubate 30 minutes at room temperature. Immunofluorescence. Recommended Positive Control: Human gastrointestinal tumor.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu BST1

Target: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Andere Bezeichnung: CD175

Hintergrund: Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90 % of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator.Synonyms: Blood Group Tn Antigen