Fibrillin 1 Antikörper

Produktnummer ABIN356183

Der Maus Monoklonal Anti-Fibrillin 1-Antikörper wurde für WB, IHC (fro), IF und IEM validiert. Er ist geeignet, Fibrillin 1 in Proben von Human und Rind (Kuh) zu detektieren.

Kurzübersicht für Fibrillin 1 Antikörper (ABIN356183)

Target: Fibrillin 1 (FBN1)

Reaktivität: Human, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fibrillin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunoelectron Microscopy (IEM)

Klon: 11C1-3

Produktdetails anti-Fibrillin 1 Antikörper

Spezifität: This antibody recognises Fibrillin (Mr 350 kDa).

Produktmerkmale: Synonyms: FBN1, FBN

Aufreinigung: Purified

Immunogen: Microfibrils from zonular apparatus of bovine eye.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/50-1/100 (30-60 min at RT). (See Ref.2)Immunofluorescence. (See Ref.2)Western blotting: < / = 1 μg/mL (See Ref.2)Electron Microscopic Immunolocalization. (See Ref.2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu Fibrillin 1

Target: Fibrillin 1 (FBN1)

Andere Bezeichnung: Fibrillin-1

Hintergrund: The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear.(Ref.1) In Immunohistochemical staining of paraformaldehyde-fixed human skin, mAb 11C1.3 labels the elastic framework and more specifically the oxytalantic network close to the epidermis. The antibody also exhibits discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues.(Ref.2,3) There is an aberrant expression of fibrillin in Marfan syndrome.(Ref.4)Synonyms: FBN, FBN1

Gen-ID: 2200

UniProt: P35555

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interaktom