Der Kaninchen Polyklonal anti-Factor Inhibiting HIF-1 Antibody Antikörper wird verwendet zum Nachweis von Factor Inhibiting HIF-1 Antibody in Proben von Maus und Ratte. Er wurde validiert für ICC, IHC und WB.
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
Bindungsspezifität
Extracellular Domain, N-Term
Kreuzreaktivität
Maus, Ratte (Rattus)
Aufreinigung
Aff - Purified
Immunogen
Synthetic peptide (Rat) from the N-terminal extracellular domain conjugated to immunogenic carrier protein.
Isotyp
IgG
Applikationshinweise
Optimal working dilutions should be determined experimentally by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Lagerung
-20 °C
Target
Factor Inhibiting HIF-1 Antibody
Substanzklasse
Antibody
Hintergrund
Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration.