VPS36 Antikörper (Internal Region)

Produktnummer ABIN351331

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch VPS36 in IHC und WB. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für VPS36 Antikörper (Internal Region) (ABIN351331)

Target: VPS36 (Vacuolar Protein Sorting 36 (VPS36))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS36 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-VPS36 Antikörper

Bindungsspezifität: Internal Region

Verwendungszweck: Rabbit antibody to VPS36

Spezifität: Specific for VPS36.

Kreuzreaktivität: Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from the internal region of mouse VPS36 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu VPS36

Target: VPS36 (Vacuolar Protein Sorting 36 (VPS36))

Andere Bezeichnung: VPS36

Hintergrund: FUNCTION: Component of the ESCRT-II complex which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation possibly via its interaction with ELL. SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Nucleus. NoteL Colocalizes with ubiquitinated proteins on late endosomes.

UniProt: Q91XD6