Dr TRPL (4th Cytoplasmic Loop) Antikörper

Produktnummer ABIN351175

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in IHC und WB. Er zeigt eine Reaktivität gegenüber Drosophila melanogaster.

Kurzübersicht für Dr TRPL (4th Cytoplasmic Loop) Antikörper (ABIN351175)

Target: Dr TRPL

Reaktivität: Drosophila melanogaster

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails

Bindungsspezifität: 4th Cytoplasmic Loop

Verwendungszweck: Rabbit antibody to dr TRPL

Spezifität: Specific for TRPL.

Kreuzreaktivität: Drosophila melanogaster

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from 4th cytoplasmic loop of drosophila TRPL (Transient receptor potential like protein) conjugated to blue carrier protein was used as the antigen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Dr TRPL

Hintergrund: FUNCTION: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with trp-gamma. Activated by fatty acids metabolic stress inositols and GTP-binding proteins. SUBUNIT: Forms heteromultimers with trp-gamma and to a lower extent with trp. Interacts with FKBP59 in vivo and is found in the inaD signaling complex. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. Note: In the dark there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions.

UniProt: P48994