Reticulon 4 Antikörper (AA 460-510)

Produktnummer ABIN350522

Der Kaninchen Polyklonal Anti-Reticulon 4-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Reticulon 4 in Proben von Human zu detektieren.

Kurzübersicht für Reticulon 4 Antikörper (AA 460-510) (ABIN350522)

Target: Reticulon 4 (RTN4)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Reticulon 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Reticulon 4 Antikörper

Bindungsspezifität: AA 460-510

Verwendungszweck: Rabbit antibody to NOGO (460-510)

Spezifität: Specific for Nogo.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from AA 460-510 of human NOGO conjugated to an immunogenic carrier protein was used as the antigen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu Reticulon 4

Target: Reticulon 4 (RTN4)

Andere Bezeichnung: NOGO

Hintergrund: Function: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Note: Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain skeletal muscle and adipocytes. Isoform 4 is testis-specific.

UniProt: Q9NQC3

Pathways: Neurotrophin Signalübertragung, Regulation of Cell Size, SARS-CoV-2 Protein Interaktom