Pro-Hepcidin (AA 39-59) Antikörper

Produktnummer ABIN350367

Dieses Anti--Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von in IHC und WB. Geeignet für Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Pro-Hepcidin (AA 39-59) Antikörper (ABIN350367)

Target: Pro-Hepcidin

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 39-59

Verwendungszweck: Rabbit antibody to pro Hepcidin (39-59)

Spezifität: Specific for Hepcidin.

Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from AA 39-59 of pro region of mouse Hepcidin conjugated to blue carrier protein has been used as the antigen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Referenzen

Mohammad, Matakidou, Robbins, Lakhal-Littleton: "The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload." in: Kidney international, Vol. 100, Issue 3, pp. 559-569, (2021) (PubMed).

Antigendetails

Target: Pro-Hepcidin

Andere Bezeichnung: pro Hepcidin

Hintergrund: FUNCTION: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity. SUBCELLULAR LOCATION: Secreted. Tissue specificity: Highly expressed in the liver and to a much lesser extent in the heart.

UniProt: Q9EQ21