Prosaposin Antikörper

Produktnummer ABIN347759

Der Kaninchen Polyklonal anti-Prosaposin Antikörper wird verwendet zum Nachweis von Prosaposin in Proben von Human. Er wurde validiert für WB, ELISA und ICC.

Kurzübersicht für Prosaposin Antikörper (ABIN347759)

Target: Prosaposin (PSAP)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Prosaposin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-Prosaposin Antikörper

Spezifität: Reacts with human Saposin-B

Kreuzreaktivität (Details): May cross react with proteins from other species due to sequence homology

Aufreinigung: Antiserum

Immunogen: Synthetic peptide derived from an internal domain of human PSAP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC1:200 - 1:1 000 WB1:500 - 1:5 000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Must be reconstituted in distilled water.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 24 months

Details zu Prosaposin

Target: Prosaposin (PSAP)

Andere Bezeichnung: Proactivator Polypeptide Domain Saposin-B (PSAP)

Hintergrund: The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator.

Gen-ID: 5660

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity