Fibronectin Antikörper

Produktnummer ABIN336929

Der Kaninchen Polyklonal anti-Fibronectin Antikörper wird verwendet zum Nachweis von Fibronectin in Proben von Human. Er wurde validiert für IHC und IHC (p).

Kurzübersicht für Fibronectin Antikörper (ABIN336929)

Target: Fibronectin

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Fibronectin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Fibronectin Antikörper

Spezifität: This antibody reacts with human fibronectin in liver, tonsil, skin and kidney. Molecular Weight: Non reduced 400-440 kDa, reduced 200-220 kDa.

Immunogen: Purified human Fibronectin from human plasma

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (IHC) 1:100-1:400 for 30 minute at room temp. using polymer system or streptavidin-biotin system. Formalin-fixed paraffin-embedded (FFPE) tissue sections and cell smears require antigen retriever, boiling tissue in 10 mM citrate buffer, pH 6.0 for 10-20 minute, followed by cooling at room temp. for 20 minutes. The optimum dilution should be determined by the individual lab. Positive Control: Human kidney. Cellular Localization: Connective tissue matrix and basement membrane.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Immunized serum in10 mM PO4, 150 mM NaCl, pH 7.4, 0.05% sodium azide. HostRabbit ReagentConc. antibody

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu Fibronectin

Target: Fibronectin

Hintergrund: Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and extracellular matrix. Fibronectin is involved in cell adhesion and migration process including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They also occur as dimmer of two 200 kDa subunits. Fibronectin has been implicated in carcinoma development in lung cancer. Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents.