Amylin/DAP Antikörper

Produktnummer ABIN334637

Der Huhn Polyklonal Anti-Amylin/DAP-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, Amylin/DAP in Proben von Human zu detektieren.

Kurzübersicht für Amylin/DAP Antikörper (ABIN334637)

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Reaktivität: Human

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser Amylin/DAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Amylin/DAP Antikörper

Produktmerkmale: Expected / apparent Molecular Weight of the Antigene: 4 kDa

Aufreinigung: affinity purified

Immunogen: synthetic peptide based on human IAPP sequence: K-C-N-T-A-T-C-A-T-Q-R-L-A-N-F-L-V-H-S-S-N-N-F-G-A-I-L-S-S-T-N-V-G-S-N-T-Y

Isotyp: IgY

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: 1 : 1000 (WB), 1 : 1000 (ELISA).

Kommentare:

antibody is recognizing trimer, dimer and monomer human IAPP

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS pH 8.0 + 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Make aliquots to avoid repreated freeze-thaw cycles and working with a stock.

Lagerung: 4 °C

Details zu Amylin/DAP

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Andere Bezeichnung: IAPP

Hintergrund: Amylin, or Islet Amyloid Polypeptide (IAPP) P10997, is a 37-residue peptide hormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly 1:100 amylin:insulin ratio). Islet, or insulinoma, almyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type 2, or harboring an insulinoma. While the association of amylin with the development of type 2 diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzherimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the deleopment of type 2 diabetes.

Molekulargewicht: 4 kDa

Pathways: Hormone Activity, Feeding Behaviour