Amylin/DAP Antikörper (AA 2-7)

Produktnummer ABIN334637

Der Huhn Polyklonal anti-Amylin/DAP Antikörper wird verwendet zum Nachweis von Amylin/DAP in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für Amylin/DAP Antikörper (AA 2-7) (ABIN334637)

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Reaktivität: Human

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser Amylin/DAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Amylin/DAP Antikörper

Bindungsspezifität: AA 2-7

Verwendungszweck: Anti-IAPP | Human IAPP (amylin) 1-37, specific for the native hormone having a disulphide-bridge between Cys2-Cys7

Kreuzreaktivität (Details): Human
Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Homologie: Primates,mouse,rat,dog,seal,Chinese hamster

Aufreinigung: Purified,total IgY

Immunogen: Synthetic peptide corresponding to the human the 37 residue IAPP also known as amylin. The IAPP/amylin peptide contains a disulphide-bridge between Cys2-Cys7 Amino acid sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (disulphide link between Cys2-Cys7)

Isotyp: IgY

Anwendungsinformationen

Applikationshinweise: 1:1000 (WB), 1:1000 (ELISA)

Kommentare:

antibody is recognizing trimer, dimer and monomer human IAPP

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Purified,total IgY (chicken egg yolk immunoglobulin) in PBS pH 8. Contains 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube

Lagerung: -20 °C

Informationen zur Lagerung: Store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Details zu Amylin/DAP

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Andere Bezeichnung: IAPP

Hintergrund: Amylin, or Islet Amyloid Polypeptide (IAPP) P10997, is a 37-residue peptide hormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly 1:100 amylin:insulin ratio). Islet, or insulinoma, almyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type 2, or harboring an insulinoma. While the association of amylin with the development of type 2 diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzherimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the deleopment of type 2 diabetes.

Molekulargewicht: 3.9 kDa

Pathways: Hormone Activity, Feeding Behaviour