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CD8 Antikörper

CD8 Reaktivität: Maus FACS, IHC (fro) Wirt: Ratte Monoclonal YTS105-18 unconjugated

Produktnummer ABIN319569

Datenblatt (PDF)

Target Alle CD8 Antikörper anzeigen

CD8
Reaktivität
209

65

25

12

12

12

9

9

8

8

6

6

6

5

5

5

4

4

3

2

1

1
Maus
Wirt
243

47

36

4
Ratte
Passende Sekundärantikörper
Klonalität
293

30

2
Monoklonal
Konjugat
105

49

38

26

13

7

5

5

5

5

5

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser CD8 Antikörper ist unkonjugiert
Applikation
287

67

55

52

50

46

32

21

18

17

15

14

8

5

5

4

3

2

2

1

1

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität

SM024LE recognises a non polymorphic epitope on the mouse CD8 alpha chain. Antibodies produced by clone YTS105.18 have been reported to block MHC I dependent T-cell responses in vitro and in vivo, and induce transplantation tolerance in combination with CD4 antibodies.

Aufreinigung

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Endotoxin-Niveau

Low Endotoxin

Immunogen

Mouse spleen cells. Spleen cells from an immunised DA rat were fused with cells of the rat Y3/Ag1.2.3. myeloma cell line.

Klon

YTS105-18

Isotyp

IgG2a

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anti-CD8 (CD8) antibody (FITC)
CD8 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-31 FITC

anti-CD8 (CD8) antibody
CD8 Reaktivität: Human IHC, IP, WB, ELISA Wirt: Kaninchen Monoclonal 3C3 unconjugated Recombinant Antibody

anti-CD8 (CD8) antibody (PerCP)
CD8 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-31 PerCP

anti-CD8 (CD8) antibody (APC)
CD8 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-31 APC

anti-CD8 (CD8) antibody (PE)
CD8 Reaktivität: Cat FACS Wirt: Maus Monoclonal fCD8 PE

Applikationshinweise

Flow Cytometry: Use 10 μL of 1/50-1/100 diluted antibody to label 10^6 cells. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL

Buffer

PBS, pH 7.4 without preservatives.

Konservierungsmittel

Without preservative

Handhabung

Avoid repeated freezing and thawing.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
Target

CD8

Andere Bezeichnung

CD8 (CD8 Produkte)

Hintergrund

CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide bonds. It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells leads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact with MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated killing. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine-protein kinase p56lck.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2

Gen-ID

12525

NCBI Accession

NP_001074579

UniProt

P01731