DDC Antikörper

Produktnummer ABIN318954

Der Kaninchen Polyklonal anti-DDC Antikörper (ABIN318954) detektiert spezifisch DDC in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Rind (Kuh).

Kurzübersicht für DDC Antikörper (ABIN318954)

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Reaktivität: Ratte, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DDC Antikörper

Spezifität: This antibody recognises DOPA decarboxylase (aromatic-L-amino acid decarboxylase, DDC).

Aufreinigung: Affinity Chromatography.

Immunogen: SDS denatured, recombinant bovine DOPA decarboxylase expressed E. coli and purified from inclusion bodies.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/1000. This antibody detects a band of approximately 55 kDa in rat adrenalmedulla.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES pH 7.5, 150 mM NaCl containing 0.09 % Sodium Azide as preservative and 0.01 % BSA, 50 % Glycerol as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DDC

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Andere Bezeichnung: AADC / DDC

Hintergrund: DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.Synonyms: Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase

Gen-ID: 280762

NCBI Accession: NP_776332

UniProt: P27718

Pathways: Dopaminergic Neurogenesis