BRCC3 Antikörper (N-Term)
-
- Target Alle BRCC3 Antikörper anzeigen
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
-
Bindungsspezifität
- N-Term
-
Reaktivität
- Human, Maus, Ratte
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser BRCC3 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody recognises human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7 kDa nuclear protein.
- Aufreinigung
- Purified
- Immunogen
- An 18 amino acid peptide from near the amino terminus of human BRCC36.
- Isotyp
- IgG
- Top Product
- Discover our top product BRCC3 Primärantikörper
-
-
- Applikationshinweise
-
Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 36 kDa in MCF7 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
- Andere Bezeichnung
- BRCC3 (BRCC3 Produkte)
- Synonyme
- CXorf53 antikoerper, BRCC3 antikoerper, xtp1 antikoerper, brcc3 antikoerper, BRCC36 antikoerper, brcc36 antikoerper, C6.1A antikoerper, BRCA1/BRCA2-containing complex subunit 3 antikoerper, DEP domain containing 1B antikoerper, BRCA1/BRCA2-containing complex, subunit 3 antikoerper, BRCA1/BRCA2-containing complex subunit 3 L homeolog antikoerper, BRCC3 antikoerper, depdc1b antikoerper, brcc3 antikoerper, Brcc3 antikoerper, brcc3.L antikoerper
- Hintergrund
- BRCC36, together with BRCA1, BRCA2, Rad51 and BRCC45, forms a holoenzyme complex that possesses an ubiquitin E3 ligase activity. Studies have demonstrated that BRCC36 functions in enhancing cellular survival following DNA damage and that it is essential for ionizing radiation induced BRCA1 phosphorylation and nuclear foci formation. Research has shown that BRCC36 is aberrantly expressed in the majority of breast tumours indicating a potential role in the pathogenesis of the disease. It has been hypothesized that BRCC36 could be a potentially important target in the treatment of radiation-resistant breast tumours.Synonyms: BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRCC36, BRISC complex subunit BRCC36, C6.1A, CXorf53, Lys-63-specific deubiquitinase BRCC36
- Gen-ID
- 79184
- NCBI Accession
- NP_001018065
- UniProt
- P46736
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
-