BAG1 Antikörper (C-Term)

Produktnummer ABIN318738

Der Kaninchen Polyklonal anti-BAG1 Antikörper (ABIN318738) detektiert spezifisch BAG1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für BAG1 Antikörper (C-Term) (ABIN318738)

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BAG1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects an epitope within the C-terminal (CT) region of Bcl-2 associated athanogene-1 (BAG1).

Aufreinigung: Purified

Immunogen: 14 amino acid peptide from near the carboxy terminus of human BAG1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1 - 2g/mL, detects a band of approximately 39 kDa in PC3 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu BAG1

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Andere Bezeichnung: BAG1

Hintergrund: BAG1 is a co-chaperone protein which binds to and regulates the 70kD heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms, a predominantly cytosolic form of 36kD (BAG1S), a 46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form 50kD (BAG1L). BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.Synonyms: BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP, RAP46

Gen-ID: 573

NCBI Accession: NP_001165886

UniProt: Q99933