Six5 Antikörper

Produktnummer ABIN317916

Produktdetails anti-Six5 Antikörper

Target: Six5 (SIX5) (Homeobox protein SIX5 (SIX5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Six5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Six5 antibody detects endogenous levels of Six5 protein.(region surrounding Leu237)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Six5

Target: Six5 (SIX5) (Homeobox protein SIX5 (SIX5))

Andere Bezeichnung: SIX5 (SIX5 Produkte)

Synonyme: Dmahp antikoerper, MDMAHP antikoerper, TrexBF antikoerper, BOR2 antikoerper, DMAHP antikoerper, sine oculis-related homeobox 5 antikoerper, SIX homeobox 5 antikoerper, Six5 antikoerper, SIX5 antikoerper

Hintergrund: Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.Synonyms: DM locus-associated homeodomain protein, DMAHP, Homeobox protein SIX5, Sine oculis homeobox homolog 5

Molekulargewicht: approx. 75 kDa

Gen-ID: 147912

NCBI Accession: NP_787071

UniProt: Q8N196