KCNJ9 Antikörper

Produktnummer ABIN317838

Der Kaninchen Polyklonal anti-KCNJ9 Antikörper (ABIN317838) detektiert spezifisch KCNJ9 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für KCNJ9 Antikörper (ABIN317838)

Target: KCNJ9 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 (KCNJ9))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNJ9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KCNJ9 Antikörper

Spezifität: KIR3.3 antibody detects endogenous levels of KIR3.3 protein.(region surrounding Asp94)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu KCNJ9

Target: KCNJ9 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 (KCNJ9))

Andere Bezeichnung: KCNJ9

Hintergrund: G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbγ subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbγ dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbγ dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.Synonyms: G protein-activated inward rectifier potassium channel 3, GIRK3, Inwardly rectifier K(+) channel Kir3.3, KCNJ9, Potassium channel, inwardly rectifying subfamily J member 9

Molekulargewicht: approx. 44 kDa

Gen-ID: 3765

NCBI Accession: NP_004974

UniProt: Q92806