RXFP2 Antikörper

Produktnummer ABIN317772

Der Kaninchen Polyklonal anti-RXFP2 Antikörper (ABIN317772) detektiert spezifisch RXFP2 in WB und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für RXFP2 Antikörper (ABIN317772)

Target: RXFP2 (Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RXFP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-RXFP2 Antikörper

Spezifität: This antibody detects endogenous levels of Relaxin Receptor 2 protein.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu RXFP2

Target: RXFP2 (Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2))

Andere Bezeichnung: Relaxin Receptor 2 / RXFP2

Hintergrund: Relaxins are endocrine and autocrine/paracrine hormones belonging to the insulin gene superfamily. In several mammalian species, relaxin is best known for its role during pregnancy and parturition, when it is produced by the corpora lutea of ovaries and other reproductive tissues. The secretion of relaxin into the blood stream just before parturition results in a marked softening and lengthening of the pubic symphysis and a softening of the cervix, which facilitates the birth process. Also, by inhibiting uterine contractions, relaxin may influence the timing of parturition. Two previously characterized orphan receptors designated relaxin receptor 1 (LGR7) and 2 (LGR8) bind relaxin in several tissues, including reproductive tissues, brain, and heart. Upon ligand binding, the relaxin receptors activate adenylate cyclases through Gs proteins. Expression of the relaxin receptors in tissues other than reproductive ones suggests that they have additional physiological functions, such as regulating blood pressure and controlling vascular volume in the heart.Synonyms: G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, GPR106, GREAT, LGR8, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2

Molekulargewicht: approx. 86 kDa

Gen-ID: 122042

NCBI Accession: NP_570718

UniProt: Q8WXD0

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction