EDG4 Antikörper

Produktnummer ABIN317745

Produktdetails anti-EDG4 Antikörper

Target: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EDG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: EDG-4 antibody detects endogenous levels of EDG-4 protein.(region surrounding Leu310)

Aufreinigung: Affinity-chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu EDG4

Target: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Andere Bezeichnung: EDG-4 / LPAR2 (LPAR2 Produkte)

Synonyme: EDG-4 antikoerper, EDG4 antikoerper, LPA-2 antikoerper, LPA2 antikoerper, lpa2 antikoerper, Gpbar1 antikoerper, Edg4 antikoerper, IPA2 antikoerper, Pbx4 antikoerper, RGD1561336 antikoerper, zgc:101053 antikoerper, lysophosphatidic acid receptor 2 antikoerper, lysophosphatidic acid receptor 2 S homeolog antikoerper, G protein-coupled bile acid receptor 1 antikoerper, growth hormone releasing hormone receptor antikoerper, lysophosphatidic acid receptor 2a antikoerper, LPAR2 antikoerper, lpar2.S antikoerper, GPBAR1 antikoerper, Lpar2 antikoerper, GHRHR antikoerper, lpar2a antikoerper

Hintergrund: The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: EDG4, Ipa-2, LPAR2, Lysophosphatidic acid receptor 2, Lysophosphatidic acid receptor Edg-4, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

Molekulargewicht: approx. 39 kDa

Gen-ID: 9170

NCBI Accession: NP_004711

UniProt: Q9HBW0