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JIP3 Antikörper

MAPK8IP3 Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN317721
  • Target Alle JIP3 (MAPK8IP3) Antikörper anzeigen
    JIP3 (MAPK8IP3) (Mitogen-Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3))
    Reaktivität
    • 20
    • 11
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 20
    • 1
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser JIP3 Antikörper ist unkonjugiert
    Applikation
    • 12
    • 9
    • 7
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects endogenous levels of JIP-3 protein.(region surrounding Gln649)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human and Mouse.
    Aufreinigung
    Affinity Chromatography using epitope-specific Immunogen.
    Top Product
    Discover our top product MAPK8IP3 Primärantikörper
  • Applikationshinweise
    ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    JIP3 (MAPK8IP3) (Mitogen-Activated Protein Kinase 8 Interacting Protein 3 (MAPK8IP3))
    Andere Bezeichnung
    JIP-3 (MAPK8IP3 Produkte)
    Synonyme
    JIP3 antikoerper, JSAP1 antikoerper, SYD2 antikoerper, syd antikoerper, BB120594 antikoerper, D17Wsu15e antikoerper, JIP-3 antikoerper, JSAP1a antikoerper, JSAP1b antikoerper, JSAP1c antikoerper, JSAP1d antikoerper, Jip3 antikoerper, Syd2 antikoerper, mKIAA1066 antikoerper, mitogen-activated protein kinase 8 interacting protein 3 antikoerper, MAPK8IP3 antikoerper, mapk8ip3 antikoerper, Mapk8ip3 antikoerper
    Hintergrund
    C-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.Synonyms: C-jun-amino-terminal kinase-interacting protein 3, JIP3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, MAPK8IP3, Mitogen-activated protein kinase 8-interacting protein 3
    Gen-ID
    23162
    NCBI Accession
    NP_001035529
    UniProt
    Q9UPT6
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