IP6K2 Antikörper

Produktnummer ABIN317720

Der Kaninchen-Polyklonal Anti-IP6K2-Antikörper wurde für WB, IF, IHC (p) und EIA validiert. Er ist geeignet zum Nachweis von IP6K2 in Proben aus Human, Maus und Ratte. }

Kurzübersicht für IP6K2 Antikörper (ABIN317720)

Target: IP6K2 (Inositol Hexakisphosphate Kinase 2 (IP6K2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IP6K2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-IP6K2 Antikörper

Spezifität: This antibody detects endogenous levels of InsP6 kinase 2 / IP6K2 protein (region surrounding Leu188).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity-chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 15 mM Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IP6K2

Target: IP6K2 (Inositol Hexakisphosphate Kinase 2 (IP6K2))

Andere Bezeichnung: InsP6 Kinase 2 / IP6K2

Hintergrund: The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.Synonyms: IHPK2, Inositol hexakisphosphate kinase 2, P(i)-uptake stimulator, PiUS, TCCCIA00113

Molekulargewicht: approx. 52 kDa

Gen-ID: 51447

NCBI Accession: NP_001005909

UniProt: Q9UHH9