AKAP13 Antikörper

Produktnummer ABIN317612

Der Kaninchen Polyklonal anti-AKAP13 Antikörper wird verwendet zum Nachweis von AKAP13 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für AKAP13 Antikörper (ABIN317612)

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKAP13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-AKAP13 Antikörper

Spezifität: This antibody detects endogenous levels of AKAP13 Protein.(region surrounding Asp738)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500-1/1000. ELISA: 1/20000-1/40000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu AKAP13

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Andere Bezeichnung: AKAP13

Hintergrund: AKAP13 functions as a protein kinase A (PKA)-anchoring protein and acts as an adapter protein to selectively couple G alpha-13 and Rho. It contains a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins. AKAP13 augments gene activation by the estrogen receptor and activates estrogen receptor beta by a p38 MAPK-dependent pathway. AKAP13 is involved in the signaling pathways leading to cardiomyocytes hypertrophy.Synonyms: A-kinase anchor protein 13, AKAP-Lbc, BRX, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, HT31, Human thyroid-anchoring protein 31, LBC, Lymphoid blast crisis oncogene, Non-oncogenic Rho GTPase-specific GTP exchange factor, P47, Protein kinase A-anchoring protein 13

Gen-ID: 11214

NCBI Accession: NP_006729

UniProt: Q12802

Pathways: Neurotrophin Signalübertragung