Der Maus Monoklonal Anti-CD20-Antikörper wurde für FACS validiert. Er ist geeignet, CD20 in Proben von Human, Rhesusaffen, Pavian und Cynomolgus zu detektieren.
The clone 2H7 recognizes the large extracellular loop of human CD20, mapped to the peptide sequence YNCEPANPSEKNSPST. CD20, a 33-36 kDa non-glycosylated type 1 transmembrane protein, is expressed by developing, resting and mature B cells, some follicular dendritic cells, and a small subset of mature T cells. B cell CD20 expression is lost upon differentiation into plasma cells. Functionally, CD20 activation contributes to B cell activation, proliferation, and differentiation