MBP Antikörper

Produktnummer ABIN3071582

Produktdetails anti-MBP Antikörper

Target: MBP (Myelin Basic Protein (MBP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Verwendungszweck: Anti-Myelin Basic Protein Mouse Monoclonal Antibody

Spezifität: This antibody reacts with residues 130-136 in human myelin basic protein (21.5 kDa and 18.5 kDa molecular forms). It also recognizes primate, rabbit, sheep, goat, rat, and mouse myelin basic protein.

Kreuzreaktivität: Ziege, Human, Maus, Primate, Kaninchen, Ratte, Schaf

Immunogen: Purified human myelin basic protein.

Klon: MBP101

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: This antibody may be used in ELISA, immunohistochemistry, and Western blot procedures for detection and/or quantitation of myelin basic protein.ELISA: Human myelin basic protein coated on ELISA wells at 5 μg/mL, binding detected with HRP-conjugated goat anti-mouse IgG + ABTS substrate.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Konzentration: Lot specific

Buffer: PBS, pH 7.4

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: This antibody is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Details zu MBP

Target: MBP (Myelin Basic Protein (MBP))

Andere Bezeichnung: Myelin Basic Protein (MBP Produkte)

Hintergrund: Myelin basic protein,The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {PubMed:8544862}.,Myelin membrane, Peripheral membrane protein, Cytoplasmic side. Note=Cytoplasmic side of myelin., [Isoform 3]: Nucleus,MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein

UniProt: P02686