ELOVL4 Antikörper

Produktnummer ABIN307133

Der Kaninchen Polyklonal Anti-ELOVL4-Antikörper wurde für WB validiert. Er ist geeignet, ELOVL4 in Proben von Human zu detektieren.

Kurzübersicht für ELOVL4 Antikörper (ABIN307133)

Target: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ELOVL4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ELOVL4 Antikörper

Kreuzreaktivität: Human

Produktmerkmale: Elongation of very long chain fatty acids protein 4, ELOV4,Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-terminal amino acids and truncation of the protein. Elovl4 is expressed in the retina and only a limited number of mammalian other tissues, including skin, with unknown function. In a mouse model with the 5-bp deletion in the Elovl4 gene, mice in the heterozygous state (Elovl4(+/del)) demonstrate progressive photoreceptor degeneration. Homozygous mice (Elovl4(del/del)) display scaly, wrinkled skin, have severely compromised epidermal permeability barrier function, and die within a few hours after birth. Lipid analyses of epidermis from Elovl4(del/del) mice show a decrease in very long-chain fatty acids (VLFAs) in both the ceramide/glucosylceramide and the free fatty-acid fractions. ELOVL4 is required for generating VLFA critical for epidermal barrier function.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptdide derived from the human ELOV4 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (1-5 μg/mL starting dilution). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu ELOVL4

Target: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Andere Bezeichnung: ELOVL4

UniProt: Q9GZR5