TIMP2 Antikörper

Produktnummer ABIN307122

Produktdetails anti-TIMP2 Antikörper

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Huhn, Human, Maus, Schwein, Kaninchen, Zebrafisch (Danio rerio)

Produktmerkmale: CSC-21K, Metalloproteinase Inhibitor 2 precursor,TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases,gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation,branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.

Aufreinigung: Protein A/G Chromatography

Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the human TIMP-2 protein and mouse myeloma Ag8563 cells. Sequence common in mouse, rabbit, chicken, zebrafish and pig.

Klon: 3A4

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Antibody can be used for ELISA, Western blotting (1-2 μg/mL) and immunohistochemistry on formalin-fixed, paraffin-embedded tissues (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Andere Bezeichnung: Tissue Inhibitor of Matrix Metalloproteinase 2 (TIMP2) (TIMP2 Produkte)

Synonyme: CSC-21K antikoerper, DDC8 antikoerper, timp2l antikoerper, zgc:65967 antikoerper, zgc:85799 antikoerper, D11Bwg1104e antikoerper, Timp-2 antikoerper, TIMP-2 antikoerper, etID32613.12 antikoerper, fa96h09 antikoerper, timp2 antikoerper, wu:fa96h09 antikoerper, zgc:136726 antikoerper, TIMP metallopeptidase inhibitor 2 antikoerper, TIMP metallopeptidase inhibitor 2b antikoerper, tissue inhibitor of metalloproteinase 2 antikoerper, TIMP metallopeptidase inhibitor 2a antikoerper, TIMP metallopeptidase inhibitor 2 L homeolog antikoerper, TIMP2 antikoerper, timp2b antikoerper, Timp2 antikoerper, timp2a antikoerper, timp2.L antikoerper

UniProt: P16035

Pathways: cAMP Metabolic Process