Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) Antikörper

Produktnummer ABIN306920

Der Kaninchen Polyklonal anti-Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) Antikörper wird verwendet zum Nachweis von Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) Antikörper (ABIN306920)

Target: Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Western Blotting (WB)

Produktdetails

Verwendungszweck: Rabbit anti Human Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) NT

Kreuzreaktivität: Human

Produktmerkmale: EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine 1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.

Aufreinigung: Ammonium Sulfate Precipitation

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Detects EDG6 (S1P4) receptors at concentration of 5-10 μg/mL by Western blot using a human EDG6 (S1P4) receptor transfected cell line. Detects an approximately 45 kDa band in Cos cells transfected with full length human EDG6 (S1P4) . Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Antigendetails

Target: Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)

Hintergrund: Endothelial cell differentiation gene 6, N terminal, Sphingosine 1-Phosphate Receptor-4 (S1P4)

UniProt: O95977