Sphingosine 1 Phosphate 3 Receptor (EDG-3) Antikörper

Produktnummer ABIN306917

Der Kaninchen Polyklonal anti-Sphingosine 1 Phosphate 3 Receptor (EDG-3) Antikörper wird verwendet zum Nachweis von Sphingosine 1 Phosphate 3 Receptor (EDG-3) in Proben von Human und Maus. Er wurde validiert für IP und WB.

Kurzübersicht für Sphingosine 1 Phosphate 3 Receptor (EDG-3) Antikörper (ABIN306917)

Target: Sphingosine 1 Phosphate 3 Receptor (EDG-3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunoprecipitation (IP), Western Blotting (WB)

Produktdetails

Verwendungszweck: x1327k2

Kreuzreaktivität: Human, Maus

Produktmerkmale: Endothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Aufreinigung: Ammonium Sulfate Precipitation

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (5-10 μg/mL) and Immunoprecipitation (see reference 4). Optimal concentration should be evaluated by serial dilutions. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Antigendetails

Target: Sphingosine 1 Phosphate 3 Receptor (EDG-3)

Hintergrund: Endothelial cell differentiation gene 3 C-terminal, Sphingosine-1-Phosphate Receptor-3 (S1P3)

UniProt: Q99500