Fibronectin Antikörper

Produktnummer ABIN306829

Dieser Maus Monoklonal Antikörper detektiert spezifisch Fibronectin in IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Fibronectin Antikörper (ABIN306829)

Target: Fibronectin

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fibronectin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: EP5

Produktdetails anti-Fibronectin Antikörper

Verwendungszweck: Mouse anti Human Fibronectin

Kreuzreaktivität: Human, Maus

Produktmerkmale: Fibronectins are a family of plasma and extracellular matrix glycoproteins that contain multiple sites for various ligands and cells. The region of fibronectin that mediates cell adhesion in a majority of cell types is in the carboxy terminal domain and involves the binding of the Arg-Gly-Asp (RGD) sequence to a specific polypeptide cell surface receptor. Although the mechanisms of fibronectin extracellular matrix assembly are not well understood, specific antibodies have been used to determine the domains involved in matrix assembly. This antibody stains the extracellular adhesive glycoprotein of fibronectin in connective tissues and vessels. It does not recognize the soluble dimeric form of fibronectin (plasma fibronectin) but strongly stains matrix fibronectin in tissues. Animal biodistribution experiments have shown that after intravenous administration, this antibody localizes to tumor vessels where it binds to the underlying basement membrane. The antigen is not accessible in normal tissues to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.

Aufreinigung: Protein A/G Chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Antibody can be used for staining of human and mouse frozen and paraffin-embedded tissue sections. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu Fibronectin

Target: Fibronectin

Hintergrund: Fibronectin

UniProt: P02751