LEF-1 Transactivation Domain Antikörper

Produktnummer ABIN306723

Der Maus Monoklonal anti-LEF-1 Transactivation Domain Antikörper (Klon 3A12) (ABIN306723) detektiert spezifisch LEF-1 Transactivation Domain in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für LEF-1 Transactivation Domain Antikörper (ABIN306723)

Target: LEF-1 Transactivation Domain

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Applikation: Western Blotting (WB)

Klon: 3A12

Produktdetails

Verwendungszweck: Mouse anti Human LEF-1 transactivation domain

Kreuzreaktivität: Human

Produktmerkmale: Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 236-242 of LEF-1. This region is found within the transactivation domain of LEF-1. However, it is not present in some splice variants.

Aufreinigung: Protein A/G Chromatography

Immunogen: .

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Antibody detects amino acids 236-242 of human LEF-1. Epitope is missing in some splice variants. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Antigendetails

Target: LEF-1 Transactivation Domain

Hintergrund: Anti-Lymphoid Enhancer Factor-1, Transactivation Domain (amino acids 236-242) Monoclonal Antibody

UniProt: Q9UJU2