Nerve Growth Factor Antikörper

Produktnummer ABIN306610

Dieser Maus Monoklonal Antikörper detektiert spezifisch Nerve Growth Factor in IP, EIA und InhA. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Rind (Kuh) und Viper.

Kurzübersicht für Nerve Growth Factor Antikörper (ABIN306610)

Target: Nerve Growth Factor (NGF)

Reaktivität: Human, Maus, Rind (Kuh), Viper

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Nerve Growth Factor Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Inhibition Assay (InhA)

Klon: AS18

Produktdetails anti-Nerve Growth Factor Antikörper

Verwendungszweck: Mouse anti Human NGF (Nerve Growth Factor)

Produktmerkmale: Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90 % homology between the two species. Recently, it has been shown that cells which do not normally respond to NGF only express low affinity receptors from transfected NGF genes but cells which normally are NGF-responsive express high affinity receptors from the same NGF sequences. This supports the hypothesis that the high affinity receptors have a unique component in addition to the subunit common to the low affinity receptors.

Aufreinigung: Protein A/G Chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Antibody can be used for immunoprecipitation, EIA and for neutralizing NGF in functional studies. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml

Buffer: phosphate buffered saline, no preservative

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Aliquot to avoid freeze/thaw cycles

Details zu Nerve Growth Factor

Target: Nerve Growth Factor (NGF)

Andere Bezeichnung: NGF (Nerve Growth Factor)

Hintergrund: NGF, hNGF, Beta-nerve growth factor, Beta-NGF, NGF, NGFB

UniProt: P01138, P13600, P01139

Pathways: Regulation of Cell Size