MAGI (PDZ 4-5) Antikörper

Produktnummer ABIN306589

Dieser Schaf Polyklonal Antikörper detektiert spezifisch MAGI (PDZ 4-5) in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MAGI (PDZ 4-5) Antikörper (ABIN306589)

Target: MAGI (PDZ 4-5) (MAGI) (Membrane AssociatedGuanalyate Kinase (PDZ 4-5) (MAGI))

Reaktivität: Human

Wirt: Schaf

Klonalität: Polyklonal

Applikation: Western Blotting (WB)

Produktdetails anti-MAGI (PDZ 4-5) Antikörper

Verwendungszweck: Sheep anti Human Guanalyate Kinase (PDZ 4-5) (MAGI)

Produktmerkmale: Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is then followed by 6 PDZ domains.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Recombinant protein corresponding to PDZ domains 4-5 of MAGI-3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody detects MAGI-3 by Western blot at 1-10 μg/mL. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml

Buffer: phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu MAGI (PDZ 4-5)

Target: MAGI (PDZ 4-5) (MAGI) (Membrane AssociatedGuanalyate Kinase (PDZ 4-5) (MAGI))

Hintergrund: Sheep anti-Membrane-associated guanylate cyclase of inverted orientation-3, PSD95 DiscsLarge Z01 domains 4-5

UniProt: Q9H2V6