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Filaggrin Antikörper (AA 1-261)

Der Kaninchen Polyklonal Anti-Filaggrin-Antikörper wurde für IHC und WB validiert. Er ist geeignet, Filaggrin in Proben von Human zu detektieren.
Produktnummer ABIN3044525

Kurzübersicht für Filaggrin Antikörper (AA 1-261) (ABIN3044525)

Target

Alle Filaggrin (FLG) Antikörper anzeigen
Filaggrin (FLG)

Reaktivität

  • 114
  • 21
  • 11
Human

Wirt

  • 67
  • 58
Kaninchen

Klonalität

  • 73
  • 52
Polyklonal

Konjugat

  • 57
  • 15
  • 9
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Filaggrin Antikörper ist unkonjugiert

Applikation

  • 87
  • 47
  • 42
  • 28
  • 22
  • 19
  • 15
  • 13
  • 8
  • 8
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), Western Blotting (WB)
  • Bindungsspezifität

    • 38
    • 31
    • 8
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-261

    Verwendungszweck

    Anti-Filaggrin/FLG Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-Filaggrin/FLG Antibody Picoband® (ABIN3044525). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E. coli-derived human Filaggrin recombinant protein (Position: M1-R261).

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Kypriotou, Magdalini, Huber, Marcel, Hohl, Daniel (September 2012)."The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family". Experimental Dermatology 21 (9): 643-649. 2. Markova, NG, Marekov, LN, Chipev, CC, Gan, SQ, Idler, WW, Steinert, PM (January 1993). "Profilaggrin is a major epidermal calcium-binding protein.". Molecular and Cellular Biology 13 (1): 613-25.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    Filaggrin (FLG)

    Andere Bezeichnung

    FLG

    Hintergrund

    Synonyms: Filaggrin,FLG,

    Tissue Specificity: Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417). .

    Background: In humans, profillagrin is encoded by the?FLG?gene, which is part of the S100 fused-type protein (SFTP) family within the?epidermal differentiation complex?on?chromosome 1q21. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.

    Molekulargewicht

    435 kDa

    Gen-ID

    2312

    UniProt

    P20930

    Pathways

    Sensory Perception of Sound, Stem Cell Maintenance
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