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MTA1 Antikörper (C-Term)

Dieses Anti-MTA1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MTA1 in WB, IHC und IHC (fro). Geeignet für Human, Maus und Ratte.
Produktnummer ABIN3044412

Kurzübersicht für MTA1 Antikörper (C-Term) (ABIN3044412)

Target

Alle MTA1 Antikörper anzeigen
MTA1 (Metastasis Associated 1 (MTA1))

Reaktivität

  • 49
  • 27
  • 21
  • 7
  • 7
  • 7
  • 7
  • 6
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 44
  • 7
  • 1
Kaninchen

Klonalität

  • 45
  • 7
Polyklonal

Konjugat

  • 39
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MTA1 Antikörper ist unkonjugiert

Applikation

  • 40
  • 22
  • 13
  • 10
  • 9
  • 7
  • 6
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 676-696, C-Term

    Verwendungszweck

    Anti-MTA1 Antibody Picoband®

    Sequenz

    ETKRAARRPY KPIALRQSQA L

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-MTA1 Antibody (ABIN3044412). Tested in IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human MTA1, identical to the related mouse and rat sequences.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Mouse, Rat, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Cui, Q., Takiguchi, S., Matsusue, K., Toh, Y., Yoshida, M. A.Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 93: 139-140, 2001. 2. Reddy, S. D. N., Pakala, S. B., Ohshiro, K., Rayala, S. K., Kumar, R.MicroRNA-661, a c/EBP-alpha target, inhibits metastatic tumor antigen 1 and regulates its functions.Cancer Res. 69: 5639-5642, 2009. 3. Zhang, X., DeSalle, L. M., Patel, J. H., Capobianco, A. J., Yu, D., Thomas-Tikhonenko, A., McMahon, S. B.Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein.Proc. Nat. Acad. Sci. 102: 13968-13973, 2005.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MTA1 (Metastasis Associated 1 (MTA1))

    Andere Bezeichnung

    MTA1

    Hintergrund

    Synonyms: Metastasis-associated protein MTA1,MTA1,

    Tissue Specificity: Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis. .

    Background: Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues.By fluorescence in situ hybridization, mapped the MTA1gene to chromosome 14q32.3. MTA1 is a component of the chromatin remodeling complex that influences gene transcription by modulating target gene chromatin. MTA1 is widely upregulated in many carcinomas.

    Sequence Similarities: Contains 1 BAH domain.

    Molekulargewicht

    80 kDa

    UniProt

    Q13330

    Pathways

    Chromatin Binding
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