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MTA1 Antikörper (C-Term)

MTA1 Reaktivität: Human, Maus, Ratte WB, IHC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044412
  • Target Alle MTA1 Antikörper anzeigen
    MTA1 (Metastasis Associated 1 (MTA1))
    Bindungsspezifität
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 676-696, C-Term
    Reaktivität
    • 46
    • 22
    • 19
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 39
    • 7
    • 1
    Kaninchen
    Klonalität
    • 40
    • 7
    Polyklonal
    Konjugat
    • 34
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTA1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 20
    • 11
    • 10
    • 9
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Verwendungszweck
    Anti-MTA1 Antibody Picoband®
    Sequenz
    ETKRAARRPY KPIALRQSQA L
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-MTA1 Antibody (ABIN3044412). Tested in IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human MTA1, identical to the related mouse and rat sequences.
    Isotyp
    IgG
    Top Product
    Discover our top product MTA1 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Mouse, Rat, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Cui, Q., Takiguchi, S., Matsusue, K., Toh, Y., Yoshida, M. A.Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 93: 139-140, 2001. 2. Reddy, S. D. N., Pakala, S. B., Ohshiro, K., Rayala, S. K., Kumar, R.MicroRNA-661, a c/EBP-alpha target, inhibits metastatic tumor antigen 1 and regulates its functions.Cancer Res. 69: 5639-5642, 2009. 3. Zhang, X., DeSalle, L. M., Patel, J. H., Capobianco, A. J., Yu, D., Thomas-Tikhonenko, A., McMahon, S. B.Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein.Proc. Nat. Acad. Sci. 102: 13968-13973, 2005.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MTA1 (Metastasis Associated 1 (MTA1))
    Andere Bezeichnung
    MTA1 (MTA1 Produkte)
    Hintergrund

    Synonyms: Metastasis-associated protein MTA1,MTA1,

    Tissue Specificity: Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis. .

    Background: Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues.By fluorescence in situ hybridization, mapped the MTA1gene to chromosome 14q32.3. MTA1 is a component of the chromatin remodeling complex that influences gene transcription by modulating target gene chromatin. MTA1 is widely upregulated in many carcinomas.

    Sequence Similarities: Contains 1 BAH domain.

    Molekulargewicht
    80 kDa
    UniProt
    Q13330
    Pathways
    Chromatin Binding
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