AIMP2 Antikörper (Middle Region)

Produktnummer ABIN3044411

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-AIMP2 Antikörper wird verwendet zum Nachweis von AIMP2 in Proben von Human, Ratte und Maus. Er wurde validiert für WB und IHC.

Kurzübersicht für AIMP2 Antikörper (Middle Region) (ABIN3044411)

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-AIMP2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-AIMP2/p38 Antibody

Sequenz: NVQRWMRSCE NLAPFNTALK LLK

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related rat,mouse sequences by three amino acids.

Produktmerkmale: Anti-AIMP2/p38 Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human AIMP2/p38, different from the related rat and mouse sequences by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, MouseWestern blot, 0.1-0.5 μg/mL, Human, Rat, Mouse

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-AIMP2 Antikörper (ABIN3044411)

Sun, Yang, Wang, Sun, Dong: "Crocin attenuates cisplatin-induced liver injury in the mice." in: Human & experimental toxicology, Vol. 33, Issue 8, pp. 855-62, (2015) (PubMed).

Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: "Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells." in: Molecular medicine reports, Vol. 10, Issue 1, pp. 89-94, (2014) (PubMed).

Zhao, Li: "Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression." in: Oncology reports, Vol. 31, Issue 6, pp. 2769-75, (2014) (PubMed).

Details zu AIMP2

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Andere Bezeichnung: AIMP2

Hintergrund:

Background: AIMP2, Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, also known as AIMP2, is an enzyme that in humans is encoded by the AIMP2 gene. AIMP2 encodes a predicted 312-amino acid protein. The AIMP2 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. AIMP2 and HRI overlap slightly and are arranged in a tail-to-tail fashion. AIMP2 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. AIMP2 is transcribed in the opposite ion compared to HRI and PMS2. AIMP2 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex. AIMP2 can work as a mediator of TGF-beta signaling and its functional importance in the control of MYC during lung differentiation.

Gene Full Name: aminoacyl tRNA synthetase complex interacting multifunctional protein 2

Sequence Similarities: Contains 1 GST C-terminal domain.

Molekulargewicht: 30 kDa

Gen-ID: 7965

UniProt: Q13155