IFITM1 Antikörper (N-Term)

Produktnummer ABIN3044336

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-IFITM1 Antikörper wird verwendet zum Nachweis von IFITM1 in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für IFITM1 Antikörper (N-Term) (ABIN3044336)

Target: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFITM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-IFITM1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Anti-IFITM1 Antibody

Sequenz: MHKEEHEVAV LGPPPST

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-IFITM1 Antibody. Tested in IHC, WB applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human IFITM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human, -Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, HumanWestern blot, 0.1-0.5 μg/mL, Human

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-IFITM1 Antikörper (ABIN3044336)

Ma, Zhang, Fu, Xia, Zhan, Li, Wang, Wu: "Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression." in: Oncology reports, Vol. 23, Issue 6, pp. 1569-76, (2010) (PubMed).

Xu, Yang, Hu: "Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation." in: Acta biochimica et biophysica Sinica, Vol. 41, Issue 6, pp. 488-94, (2009) (PubMed).

Yang, Xu, Chen, Hu: "IFITM1 plays an essential role in the antiproliferative action of interferon-gamma." in: Oncogene, Vol. 26, Issue 4, pp. 594-603, (2007) (PubMed).

Details zu IFITM1

Target: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Andere Bezeichnung: IFITM1

Hintergrund:

Background: Interferon-induced Transmembrane Protein 1 (IFITM1), also called Interferon-induced Protein 17 (IFI17). IFITM1 activity is required for primordial germ cells (PGCs) transit from the mesoderm into the endoderm, and that it appears to act via a repulsive mechanism, such that PGCs avoid Ifitm1-expressing tissues. It is mapped to Chr.11 and belongs to the family of interferon-induced transmembrane proteins (Ifitm/mil/fragilis), which encodes cell surface proteins that may modulate cell adhesion and influence cell differentiation. Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on their pattern of induction in interferon-sensitive and -resistant cell lines and the ability of a membrane fraction enriched in 17- kDa proteins to inhibit cell growth.

Gene Full Name: interferon induced transmembrane protein 1

Sequence Similarities: Belongs to the intermediate filament family.

Molekulargewicht: 70-74 kDa

Gen-ID: 8519

UniProt: P13164